Volume 10 Issue 1 - March 2018

  • 1. Study on sialic acid as biomarker of cancer

    Authors : Arpita Chatterjee, Sudip Kumar Sinha, Gopeswar Mukherjee

    Pages : 63-68

    DOI : http://dx.doi.org/10.21172/1.101.11

    Keywords : Total serum sialic acid, lipid associated sialic acid, TSA/TP factor.

    Abstract :

    In the present study total serum sialic acid (TSA), lipid associated sialic acid (LASA), total protein (TP) and TSA/TP factor was estimated in 53 patients suffering with breast, lungs, gastrointestinal and other types of cancer, and compared to 50 healthy controls. The patients enrolled were newly diagnosed for cancer but without having any treatment till before the experiment was performed. A significant increase in TSA and LASA was observed along with decrease in TP values in all the cases of cancer. When TSA was normalized to TP, the value found was increased significantly in cancer patients in comparison to normal cases. The specificity and sensitivity study of TSA, LASA and TSA/TP showed that TSA/TP had greater specificity and sensitivity when comparing to other two. Thus it can be inferred that these are sensitive markers regarding early detection of malignancy and useful in monitoring cancer patients.

    Citing this Journal Article :

    Arpita Chatterjee, Sudip Kumar Sinha, Gopeswar Mukherjee, "Study on sialic acid as biomarker of cancer", https://www.ijltet.org/journal_details.php?id=928&j_id=4379, Volume 10 Issue 1 - March 2018, 63-68, #ijltetorg