Volume 10 Issue 2 - April 2018

  • 1. In silico analysis of single nucleotide polymorphisms (snps) in human nlrp7 gene association with rhms

    Authors : Nasreen Sultana, K. Kasturi

    Pages : 20-27

    DOI : http://dx.doi.org/10.21172/1.102.05

    Keywords : Single nucleotide polymorphisms, familial recurrent hydatidiform mole, computational tools.

    Abstract :

    Single nucleotide polymorphisms (SNPs), present in the protein encoding regions of the genome can affect the structure and capacity of a protein. In this work, we have analyzed the mutations that can alter the function of the NLRP7 gene through computational strategies. NALP7 has recently been recognize as the adroit gene for familial repetitive Hydatidiform mole (FRHM), a attenuate autosomal (latent) recessive condition in which influences the people who have intermittent molar pregnancies of diploid bi-parental beginning. Here, we applied the distinctive computational tools like SIFT, polyphen, PROVEAN, I-Mutant-2.0, PANTHER, Phd-Snp, SNPs&GO, MutPred, NetsurfP. To understand the atomic arrangement in 3D space, the native and aberrant structures were modeled. Finally the structural analyses of native and mutant NLRP7 proteins were explored by utilizing Pymol and Hope project. Our Insilico analysis proposed that D657A variants of NLRP7 could directly or indirectly destabilize the amino acid interactions and hydrogen bond networks clarifies the functional deviations of protein to some extent. Screening of NLRP7, D657V variant might be valuable for disease molecular diagnosis and also to design the molecular inhibitors of NLRP7 pathways.

    Citing this Journal Article :

    Nasreen Sultana, K. Kasturi, "In silico analysis of single nucleotide polymorphisms (snps) in human nlrp7 gene association with rhms", https://www.ijltet.org/journal_details.php?id=930&j_id=4465, Volume 10 Issue 2 - April 2018, 20-27, #ijltetorg