Volume 10 Issue 1 - March 2018

  • 1. Study of chondrogenesis in murine mesenchymal stem cells as a cell therapy in cartilage repair by in silico approach

    Authors : Ruth Keziah M

    Pages : 105-112

    DOI : http://dx.doi.org/10.21172/1.101.17

    Keywords : Mesenchymal, cytoscape, chondrocytic differentiation,multipotent

    Abstract :

    Mesenchymal stem cells (MSCs) are multipotent cells able to differentiate intoseveral mesenchymal lineages, classically derived from bone marrow. We have focused our attention on the genes responsible for the chondrogenic differentiation of murine MSCs by analysing the interaction of genes and microarray data analysis. For this purpose, softwares like Cytoscape, Polar mapper, Bio interpreter, Gene Spring. This study provides an overall view of the transcriptions factors and their protein interaction involved in the chondrocytic differentiation of MSCs. The proper knowledge about the transcription factors and their mechanism is important for the efficient chondrocytic differentiation and this will be a milestone for the development of cartilage tissue engineering. The identified transcription factors and proteins can be visualised in the invitro conditions and this can increase the efficiency of cartilage formation.

    Citing this Journal Article :

    Ruth Keziah M, "Study of chondrogenesis in murine mesenchymal stem cells as a cell therapy in cartilage repair by in silico approach", https://www.ijltet.org/journal_details.php?id=928&j_id=4385, Volume 10 Issue 1 - March 2018, 105-112, #ijltetorg