Volume 8 Issue 4 - July 2017

  • 1. Simultaneous determination of drugs used for chronic active gastritis disease by chemometric methods

    Authors : Guzide Pekcan Ertokus, Kazım Bagrıacık

    Pages : 173-178

    DOI : http://dx.doi.org/10.21172/1.84.27

    Keywords : clarithromycin, amoxicillin, lansoprazole, PLSR, PCR.

    Abstract :

    The spectrophotometric-chemometric analysis of clarithromycin amoxicillin and lansoprazole that are used for the eradication of Helicobacter pylori (HP) was analysis without any prior reservation. The used chemometric methods were principal component regression (PCR) and partial least squares regression (PLSR). In the first step, the synthetic mixtures including clarithromycin, amoxicillin and lansoprazole were prepared and absorbance values are obtained from spectrophotometry. Absorbance and concentration values were used in Minitab and other chemometric programs to calculate estimated concentrations with PCR and PLSR. Because of recovery and standard deviation were accomplished, this study encouraged us to applied for drug analysis. The second step, in drug tablets was calculated clarithromycin, amoxicillin and lansoprazole amounts.

    Citing this Journal Article :

    Guzide Pekcan Ertokus, Kazım Bagrıacık, "Simultaneous determination of drugs used for chronic active gastritis disease by chemometric methods", https://www.ijltet.org/journal_details.php?id=918&j_id=3857, Volume 8 Issue 4 - July 2017, 173-178, #ijltetorg